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THE HAEMATOLOGICAL PROFILE OF THE SPRAGUE-DAWLEY OUTBRED ALBINO RAT IN NSUKKA, NIGERIA
Hepatoprotective and antioxidant activities of Pterocarpus santalinoides methanol leaf extract.
Some biochemical perturbations may modify the understanding of trypanotolerance in the West African Dwarf sheep infected with Trypanosoma brucei brucei and Trypanosoma congolense
Haematology, serum biochemistry and histopathological findings associated with sub-chronic administration of methanol leaf extract of Pterocarpus santalinoides DC in albino rats.
Reference values for certain serum biochemical markers of liver damage in apparently healthy Red Sokoto goats.
This study evaluated the haematological profile of the domestic pigeon (Columba livia domestica). Seventy five pigeons were acquired for the study from three locations (Ibagwa, Orba and Enugu-Ezike) where pigeons are raised in Nsukka agro-ecological zone, Enugu State, Nigeria, but after two weeks of acclimatization 64 of the pigeons (34 females and 30 males) that were considered apparently healthy were used for the study. One ml of blood was collected from each pigeon by jugular venipuncture for evaluation of the haematological parameters. The haematological characteristics of the pigeons were determined using standard methods. The overall mean values obtained for the haematological parameters were as follows: packed cell volume (PCV) – 44.54 ± 4.73%; haemoglobin concentration (Hb) – 12.89 ± 1.55 g/dl; red blood cell (RBC) count – 3.34 ± 0.38 (106/ul); mean corpuscular volume (MCV) – 133.86 ± 19.37 fl; mean corpuscular haemoglobin (MCH) – 38.67 ± 5.34 pg; mean corpuscular hemoglobin concentration (MCHC) – 28.97 ± 2.59 g/dl; leukocyte counts (103/ul): total leukocyte – 23.36 ± 7.06; lymphocyte – 10.66 ± 3.49, heterophil – 7.80 ± 2.89, monocyte count – 2.32 ± 0.93, eosinophil count – 2.25 ± 0.89, and basophil – 0.24 ± 0.30. There were no significant differences (p>0.05) between the males and females in all the haematological parameters evaluated and the body weights. There were however significant variations (p
This study investigated the occurrence of wounds in Nigerian horses. The study population was 1,621 horses sold at the Obollo Afor horse lairage in Enugu State, Nigeria, during a 6-month period: 3 months of dry season and 3 months of rainy season (February–April and June–August 2012). A total of 207 horses were systematically sampled and subjected to a comprehensive physical examination. Those with wounds were marked, recorded, and clinically examined. Of the 207 horses sampled, 21 (10.1%) had wounds. The body distribution of the wounds was 9.5% head, 9.5% forelimbs, 19.1% hind limbs, 4.8% tail, 14.3% flank, 9.5% loin, 19.1% hip, 9.5% barrel, and 4.8% croup. The occurrence of the wounds was not significantly associated with sex or season, but the occurrence in adults was significantly (p < .05) higher than that in the young and aged horses. It was concluded that the occurrence of wounds is relatively high (10.1%), and mainly the hind limbs, hip, and flank of adult horses are affected. It was recommended that horse guardians and handlers should be properly educated on the care of horses.
Co-trimoxazole is an antimicrobial drug gotten from potentiation of sulfamethoxazole with trimethoprim. It is widely used for the treatment of bacterial and protozoan infections in humans. It is also used in veterinary clinics against susceptible microorganisms, but thyroid dysfunction has raised concern especially in dogs. This study aimed to determine the effects of prolonged treatment with co-trimoxazole in euthyroid dogs. Dogs were given co-trimoxazole at 30, 60, and 120 mg/kg body weight at 12-hour intervals for 21 days. Standard procedures were used to assay total T4 and T3, thyrotropin, testosterone, aspartate aminotransferase, alanine aminotransferase, and alkaline phosphatase in serum. The thyroid gland and testes were weighed. In addition, thyroid and liver were examined histologically. Epididymal sperm count was also performed. Co-trimoxazole caused dose-dependent depression of serum thyroxine levels with severe colloid depletion, intrafollicular hemorrhage, hyperplasia, and hypertrophy of the follicular cells. The liver showed vacuolar hepatopathy. Epididymal sperm count was low in the 120 mg/kg–treated group. The study revealed that thyroid hemorrhage and lowered epididymal sperm reserve were new findings in cotrimoxazole toxicity in dogs.
This study evaluated the changes that occurred in the serum levels of calcium and phosphorus in laying hens infected with velogenic Newcastle disease (ND) virus (vNDV), and their relationship to the decrease in egg production usually associated with ND. Two hundred and forty laying hens (32 weeks old) were randomly assigned into four groups of 60 each viz: VAI – vaccinated with ND vaccines and intramuscularly inoculated with vNDV, VAU – vaccinated uninfected, UNI – unvaccinated infected and UNU – unvaccinated uninfected. At weekly intervals blood was collected from six randomly selected hens in each group for serum calcium and phosphorus assays. Groups VAI and UNI showed a significant (p < .05) drop in egg production. Serum phosphorus levels of groups VAI and UNI were significantly (p < .05) lower than those of groups VAU and UNU. There was a highly positive correlation between serum phosphorus levels and egg production which was highly significant (r = .74; p < .01). The changes in serum calcium levels of infected groups were only slight, and the relationship between serum calcium levels and egg production was low, positive and not significant (r = .26; p > .05). Drop in egg production that occurred in the ND-infected laying hens was positively strongly correlated with the drop in serum phosphorus levels.
This study assessed hematological and serum biochemical alterations associated with the occurrence of tuberculous lesions in slaughtered White Fulani cattle at Nsukka abattoir, Enugu State, Nigeria. Diagnosis was confirmed by the immunochromatographic technique and histopathology. Out of 567 cattle examined, ten (1.76%) had tuberculous lesions. The tuberculous cattle had normocytic normochromic anemia, leukocytosis, lymphocytosis, eosinophilia and an increased erythrocyte sedimentation rate. They also had significantly lower (p < 0.05) serum alanine aminotransferase, albumin and urea, and significantly higher (p < 0.05) serum globulin than the apparently healthy control animals. We concluded that the occurrence of tubercles in cattle was associated with alterations in hematological and serum biochemical parameters, which may be relevant to the establishment of an antemortem diagnosis of tuberculosis.
Contamination of Drinking Water with Inorganic Fertilizer: Effects on Reproductive Performance
A New and Simple Method of Confirmatory Detection of Mating in Albino Rats (Rattus norvegicus)
Co-administration of Na-EDTA and Diminazene Aceturate (DA) to Mice Infected with DA-resistant Trypanosoma brucei