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Antisocial behaviour has been a problem among the university students in Enugu metropolis. This could be as a result of the existence of many tertiary institutions in the city and its environs. This study was designed to identify the key causative factors of some selected anti-social behaviours such as cigarettes smoking, alcohol consumption, drug abuse, involvement in illicit sex, fighting and stealing. The factors include father’s highest education, mother’s highest education, family financial status, relationship with mother, relationship with father, relationship with friends, mother’s reaction about smoking, father’s reaction about smoking, satisfaction with personal financial status, satisfaction with own health. Survey research method was employed while simple random sampling technique was used in selecting the samples for the study. Sample of one hundred and ninety seven (197) students were drawn from among the third and final year university students of University of Nigeria, Enugu Campus, Godfrey Okoye University and Enugu State University of Technology. Data for the study were collected using questionnaires. Data collected for the study were analysed using linear regression and ANOVA.