By Maduike C. O. Ezeibe, Chigozie D. Dire, George N. Anosa, Ogechukwu N. Chikelu, Obianuju N. Okoroafor, Okechi K. Okorie, Augustine A. Ngene, Idika K. Idika, Temitope M. Ogunniran, and Ihuoma E. Ezeala
To test effect of a synthetic Aluminium-Magnesium
Silicate (AMS) on anthelmintic efficacy of
piperazine citrate (PC), 35 mice were infected by
dosing each, 0.15 ml Helignosomoides bakeri
sample which contained 200 infective larvae, per
os. Following comfirmation of establishment of
infection by faecal floatation, they were assigned
into seven groups of 5 each, and were treated
with piperazine citrate, per os, at rates of 110
mg/kg (PC), 110 mg/kg (PC in AMS), 82.5 mg/kg
(PC), 82.5 mg/kg (PC in AMS), 55 mg/kg (PC) and
55 mg/kg (PC in AMS) respectively. The seventh
group served as untreated control. Mean Eggs
Per Gramm of faeces (EPG) were 375 ± 32.27,
175 ± 14.43, 830 ± 1.04, 70 ± 12.25, 850 ± 293.06,
370 ± 58.54 and 2,200 ± 2.55 respectively. This
showed EPG reduction rates of 83%, 92%, 62%,
97%, 61% and 83% among the respective treated
groups.