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The study investigated the nutrients and phytochemical compositions of some leafy vegetables in Nigeria (Hibiscus cannabinus, Adansonia digitata, Sesamum indicum and Cassia tora leaves) and the effects of their extracts on blood glucose and lipid profile of alloxan induced diabetic rats. Two kilogrammes of each of the vegetables were bought fresh, sorted by removing extraneous material, washed with deionized water and separately pulverized using Gallenkamp mixer Kenwood –MPR 201. A half of the vegetables was used for chemical analysis and a half for methanol extract production. Standard methods were used to determine in triplicate the proximate, some minerals, vitamins, antinutrients, food toxicants, and phytochemical constituents of the fresh leaves and their methanol extracts. Animal study was carried out to ascertain the effect of the nutrients on blood glucose and lipid profile of alloxan- induced diabetic rats. Forty five male adult albino rats (150-200g) divided into nine groups of five rats each on basis of body weights were used for the study.