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PILOT SCALE-UP APPLICATION OF GUM FROM PROSOPZS AFRICANA FAMILY MIMOSACEAE (GUILL AND PERR.) TAUB, AS BINDER IN TABLET TECHNOLOGY

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Abstract

In this study, kilograms of Prosopis afiicana gum powder was processed from the ripe seeds of Prosopis afiicnna, family Mimosaceae (Guill and Perr) Taub by boiling the seeds appropriately with purified water and later soaking with 1% "/v sodium
metabisulphite solution. The gum was precipitated using suitable volumes of acetone that was later recovered and recycled for subsequent uses. The 250,um undersize (industrial grade) gum produced was used to granulate seven commonly used drug powders, namely, magnesium trisilicate, ascorbic acid, sodium bicarbonate,
chlorpheniramine maleate, vitamin-B-complex, folic acid and paracetamol using the conventional wet-granulation technique. In order to make for industrial batch size, a lOkg quantity of the formulation was granulated in each case