By Alfa. John.
'The processing technique for production of alpha and microcystalline cellulose using Sorghum bicolor and Andropogon gayanus as starting materials was established. The effect of reagent type and concentration, pH, temperature, digestion and bleaching time on the quality and yield of the powdered cellulose grades k studied. Acute toxicity test on the derived polymers was investigated using albino mice. The physicotechnical properties of the new polymeric materials were studied. A Carver hydraulic hand press was used to determine the compression and compaction characteristics of the cellulose products. The reworking potentials of the pure excipents in addition to the critical excipient concent&ions of SOMCC or AMCC in blends containing drugs were determined. Formulations of acetaminoplien, ascorbic acid and metronidazole at polymer concentrations of 30, 33.3 and 33.3% respectively were compressed using STC Tablet Machine Model THP (Shanghai).