By Dahird, Daniel
Pre-treatment, co-treatment and post-treatment protocols were employed
to study the effect of aqueous extract of Ziziphus mauritiana (Z) leaf on alcoholinduced chronic hepatotoxicity using male Wister rats. Alcohol-induced liver damage was achieved by administering 40% alcohol solution (1 m11100 g
bwlday) for 6 weeks. A significant decrease (pc0.05) in body weight (bw) of
rats in all the groups that ingested alcohol was observed up to week 4 compared
to bw of control rats. However, at week 5, groups that were pre-treated with 400
mglkg bw of aqueous extract of Z or 100 mglkg silymarin prior to alcohol
administration had significant increase (p